Synthesis of Enantiomeric Aminoalkylcarbamoylphosphonates and Their Evaluation as Dual-Action Anticancer MMP and Carbonic Anhydrase Inhibitors

Keyphrases

• Enantiomeric 100%
• Anticancer 100%
• Carbonic Anhydrase Inhibitors 100%
• Dual Action 100%
• Carbacylamidophosphate 100%
• Matrix metalloproteinase-2 (MMP-2) 66%
• Inhibitory Activity 33%
• IC50 33%
• Metastasis 33%
• Racemic 33%
• Inhibitory Action 33%
• Biological Properties 33%
• Circular Dichroism 33%
• Extracellular Enzymes 33%
• X-ray Crystallography 33%
• IC50 Value 33%
• In Vitro Evaluation 33%
• NMR Experiments 33%
• Stereoselective Synthesis 33%
• Functional Group Transformation 33%
• CA XII 33%
• Carbonic Anhydrase IX 33%
• Chiral Shift Reagents 33%
• Enantiomeric Purity 33%
• Carbonic Anhydrase XII 33%
• Active Inhibitor 33%

Chemistry

• NMR Shift Reagent 20%