Synthesis of indazole motifs and their medicinal importance: An overview

Digambar D. Gaikwad; Archana D. Chapolikar; Chandrashekhar G. Devkate; Khandu D. Warad; Amit P. Tayade; Rajendra P. Pawar; Abraham J. Domb

doi:10.1016/j.ejmech.2014.11.029

Synthesis of indazole motifs and their medicinal importance: An overview

Digambar D. Gaikwad^*
, Archana D. Chapolikar
, Chandrashekhar G. Devkate
, Khandu D. Warad
, Amit P. Tayade
, Rajendra P. Pawar
, Abraham J. Domb

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Short survey › peer-review

314 Scopus citations

Abstract

Indazoles is an important class of heterocyclic compounds having a wide range of biological and pharmaceutical applications. There is enormous potential in the synthesis of novel heterocyclic systems to be used as building blocks for the next generation of pharmaceuticals as anti-bacterial, anti-depressant and anti-inflammatory. Fused aromatic 1H and 2H-indazoles are well recognized for anti-hypertensive and anti-cancer properties. The present review focuses on novel routes of their synthesis and various biological activities.

Original language	English
Pages (from-to)	707-731
Number of pages	25
Journal	European Journal of Medicinal Chemistry
Volume	90
DOIs	https://doi.org/10.1016/j.ejmech.2014.11.029
State	Published - 27 Jan 2015

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Masson SAS.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antipsychotic
Antiretroviral
Antitumor
Axitinib
Chronic pain
Narcotic

Access to Document

10.1016/j.ejmech.2014.11.029

Cite this

@article{67a94eeec315471484cd5cfaa130c32c,

title = "Synthesis of indazole motifs and their medicinal importance: An overview",

abstract = "Indazoles is an important class of heterocyclic compounds having a wide range of biological and pharmaceutical applications. There is enormous potential in the synthesis of novel heterocyclic systems to be used as building blocks for the next generation of pharmaceuticals as anti-bacterial, anti-depressant and anti-inflammatory. Fused aromatic 1H and 2H-indazoles are well recognized for anti-hypertensive and anti-cancer properties. The present review focuses on novel routes of their synthesis and various biological activities.",

keywords = "Antipsychotic, Antiretroviral, Antitumor, Axitinib, Chronic pain, Narcotic",

author = "Gaikwad, \{Digambar D.\} and Chapolikar, \{Archana D.\} and Devkate, \{Chandrashekhar G.\} and Warad, \{Khandu D.\} and Tayade, \{Amit P.\} and Pawar, \{Rajendra P.\} and Domb, \{Abraham J.\}",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Masson SAS.",

year = "2015",

month = jan,

day = "27",

doi = "10.1016/j.ejmech.2014.11.029",

language = "אנגלית",

volume = "90",

pages = "707--731",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson s.r.l.",

}

TY - JOUR

T1 - Synthesis of indazole motifs and their medicinal importance

T2 - An overview

AU - Gaikwad, Digambar D.

AU - Chapolikar, Archana D.

AU - Devkate, Chandrashekhar G.

AU - Warad, Khandu D.

AU - Tayade, Amit P.

AU - Pawar, Rajendra P.

AU - Domb, Abraham J.

PY - 2015/1/27

Y1 - 2015/1/27

N2 - Indazoles is an important class of heterocyclic compounds having a wide range of biological and pharmaceutical applications. There is enormous potential in the synthesis of novel heterocyclic systems to be used as building blocks for the next generation of pharmaceuticals as anti-bacterial, anti-depressant and anti-inflammatory. Fused aromatic 1H and 2H-indazoles are well recognized for anti-hypertensive and anti-cancer properties. The present review focuses on novel routes of their synthesis and various biological activities.

AB - Indazoles is an important class of heterocyclic compounds having a wide range of biological and pharmaceutical applications. There is enormous potential in the synthesis of novel heterocyclic systems to be used as building blocks for the next generation of pharmaceuticals as anti-bacterial, anti-depressant and anti-inflammatory. Fused aromatic 1H and 2H-indazoles are well recognized for anti-hypertensive and anti-cancer properties. The present review focuses on novel routes of their synthesis and various biological activities.

KW - Antipsychotic

KW - Antiretroviral

KW - Antitumor

KW - Axitinib

KW - Chronic pain

KW - Narcotic

UR - https://www.scopus.com/pages/publications/84928242567

U2 - 10.1016/j.ejmech.2014.11.029

DO - 10.1016/j.ejmech.2014.11.029

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.shortsurvey???

C2 - 25506810

AN - SCOPUS:84928242567

SN - 0223-5234

VL - 90

SP - 707

EP - 731

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

ER -

Synthesis of indazole motifs and their medicinal importance: An overview

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this