Synthesis of novel urea bridged macrocyclic molecules using BTC

Mattan Hurevich*, Yaniv Barda, Chaim Gilon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Cyclic ureas have interesting pharmacological properties that have led to their use as analogs of bioactive compounds. Several synthetic routes for urea formation by cyclization of diamines are known, based on the nucleophilic reaction of the amines with phosgene or phosgene derivatives. We have developed a procedure for a triphosgene mediated, on-resin urea cyclization. Four novel urea macrocyclic molecules were synthesized in order to demonstrate the feasibility of this method.

Original languageAmerican English
Pages (from-to)617-625
Number of pages9
JournalHeterocycles
Volume73
Issue numberC
DOIs
StatePublished - 2007

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