Synthesis of substituted 14-Crown-4 compounds

Bronislaw P. Czech, Wolodymyr Zazulak, Anand Kumar, Uriel Olsher, Hadar Feinberg, Shmuel Cohen, Gil Shoham, N. Kent Dalley, Richard A. Bartsch

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Seventeen new substituted 14-crown-4 derivatives 3-10, 35-40, 42, 45 and 46 are described. A series of nine compounds 2-10 with two, three or four substituents in the 6- and/or 13-positions was synthesized in good yields from the appropriate diols and ditosylates using improved cyclization conditions. The solid state structures of 6,6,13,13-tetra(benzyloxymethyl)-14-crown-4 (8) and lithium thiocyanate complexes of trans- and cis-6,13-bis(spiro-2,2-dichlorocyclopropyl)-14-crown-4 (45) and (46), respectively, have been determined.

Original languageAmerican English
Pages (from-to)1389-1400
Number of pages12
JournalMathematical Problems in Engineering
Issue number6
StatePublished - 1 Oct 1992


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