Systematic solid-phase synthesis of linear pseudooligolysines containing multiple adjacent CH₂NH amide bond surrogates: Potential agents for gene delivery

Keyphrases

• Gene Delivery 100%
• Solid-phase Synthesis 100%
• Amide Bond Surrogate 100%
• Methanol 50%
• Resin 50%
• Physiological Condition 50%
• Polyethyleneimine 50%
• Tight 50%
• Peptide Bond 50%
• Positive Charge 50%
• Plasmid DNA (pDNA) 50%
• Enhanced Resistance 50%
• Solid Phase 50%
• Trypsin 50%
• Oligomeric 50%
• Up to Five 50%
• Reductive Alkylation 50%
• Free Amine 50%
• Fmoc 50%
• Alkylation Reaction 50%
• Oligolysine 50%
• Peptide-bond Isostere 50%
• Spermine Analogues 50%
• Sodium Cyanoborohydride 50%
• DNA Carrier 50%

Chemistry

• Carboxamide 100%
• Deoxyribonucleic Acid 100%
• Peptide 100%
• Methanol 50%
• Sodium 50%
• Reductive Alkylation 50%
• Spermine 50%
• Enzymatic Hydrolysis 50%
• Alkylation 50%
• Imine 50%
• Plasmid 50%
• Hydrolysis 50%
• Amine 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Peptide Bond 100%
• Carboxamide 100%
• Gene Delivery 100%
• Spermine 50%
• Plasmid DNA 50%
• Polyethyleneimine 50%
• Amine 50%
• Sodium 50%