Systemic amyloidosis in a cheetah (Acinonyx jubatus)

Ron Ofri*, Abraham Nyska, Reinhold P. Linke, Shmuel Shtrasburg, Avi Livneh, Rivka Gal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


A captive, 9 year old female cheetah (Acinonyx jubatus) with progressive signs of chronic renal failure was euthanized. Histologic studies of the kidney revealed severe glomerular and medullary amyloidosis. The amyloid stained positively with Congo red and showed green birefringence under polarized light. Based on potassium permanganate sensitivity and the immunohistochemical reaction with monoclonal antibodies, the renal amyloid was classified as AA. Amyloid was also deposited in the liver and heart. Electrophoresis of heart and kidney tissue showed two protein bands reflecting serum amyloid A. This is the first detailed report of amyloidosis leading to renal failure in a highly endangered species.


  • AA amyloid
  • Cheetah
  • Chronic renal failure
  • Feline
  • Kidney


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