Abstract
A captive, 9 year old female cheetah (Acinonyx jubatus) with progressive signs of chronic renal failure was euthanized. Histologic studies of the kidney revealed severe glomerular and medullary amyloidosis. The amyloid stained positively with Congo red and showed green birefringence under polarized light. Based on potassium permanganate sensitivity and the immunohistochemical reaction with monoclonal antibodies, the renal amyloid was classified as AA. Amyloid was also deposited in the liver and heart. Electrophoresis of heart and kidney tissue showed two protein bands reflecting serum amyloid A. This is the first detailed report of amyloidosis leading to renal failure in a highly endangered species.
| Original language | English |
|---|---|
| Pages (from-to) | 98-103 |
| Number of pages | 6 |
| Journal | Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis |
| Volume | 4 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1997 |
Keywords
- AA amyloid
- Cheetah
- Chronic renal failure
- Feline
- Kidney
