TY - JOUR
T1 - T-2 toxin effect on bacterial infection and leukocyte functions
AU - Yarom, R.
AU - Sherman, Y.
AU - More, R.
AU - Ginsburg, I.
AU - Borinski, R.
AU - Yagen, B.
PY - 1984/8
Y1 - 1984/8
N2 - The effects of T-2 toxin on bacterial infection and leukocyte function and structure were examined in vivo and in vitro. Rats were innoculated with staphylococci after pretreatment with or without T-2 toxin. The T-2 pretreated rats failed to mount a cellular response to the bacteria. Blood and bone marrow cells were markedly suppressed by the T-2 toxin, the myeloid series being the most affected. In vitro studies with human leukocytes showed that small, nonkilling doses of T-2 toxin inhibited chemotaxis, chemiluminescence stimulated by bacteria, and phagocytosis of bacteria. It was concluded that this inhibition may contribute towards sepsis and rapid onset of death in T-2 toxin poisoning.
AB - The effects of T-2 toxin on bacterial infection and leukocyte function and structure were examined in vivo and in vitro. Rats were innoculated with staphylococci after pretreatment with or without T-2 toxin. The T-2 pretreated rats failed to mount a cellular response to the bacteria. Blood and bone marrow cells were markedly suppressed by the T-2 toxin, the myeloid series being the most affected. In vitro studies with human leukocytes showed that small, nonkilling doses of T-2 toxin inhibited chemotaxis, chemiluminescence stimulated by bacteria, and phagocytosis of bacteria. It was concluded that this inhibition may contribute towards sepsis and rapid onset of death in T-2 toxin poisoning.
UR - https://www.scopus.com/pages/publications/0021187132
U2 - 10.1016/0041-008X(84)90076-0
DO - 10.1016/0041-008X(84)90076-0
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C2 - 6464023
AN - SCOPUS:0021187132
SN - 0041-008X
VL - 75
SP - 60
EP - 68
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
IS - 1
ER -