T cell mulfunction in the tumor environment

Eitan Yefenof*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The cancer microenvironment may be envisaged as a battlefield of a fight between the host's immune system and the tumor. An army of T lymphocytes, which are trained to combat bacterial and viral infections, is mobilized to attack the tumor, but most of the times succumbs to its powers and lose the war. A major reason for this failure is the unique composition of the cancer microenvironment, which is shaped by the tumor in favor of its progression. The immunosuppressive environment of the tumor makes it a hard place for T cells to exert their otherwise powerful effector functions. The study of the cancer microenvironment yields important insights into the nature of the tumor protective shields surrounding the tumor. Recent studies bring new prospects for intervention therapies based on recruitment and activation of T cells at the cancer microenvironment.

Original languageEnglish
Title of host publicationThe Tumor Immunoenvironment
PublisherSpringer Netherlands
Pages325-338
Number of pages14
ISBN (Electronic)9789400762176
ISBN (Print)940076216X, 9789400762169
DOIs
StatePublished - 1 Jan 2013

Bibliographical note

Publisher Copyright:
© 2013 Springer Science+Business Media Dordrecht. All rights are reserved.

Keywords

  • Cancer
  • Cytotoxic lymphocytes
  • Immunosuppression
  • Regulatory T cells
  • T cells
  • Tumor microenvironment

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