Abstract
Here we review T-cell vaccination (TCV), a cell-based, generic approach to immune regulation. We describe TCV clinical trials in multiple sclerosis and other autoimmune diseases; we analyze the immune regulatory mechanisms activated by TCV; we examine the potential of public T cells as TCV mediators, and we discuss the physiology of immune regulation in the light of TCV.
Original language | American English |
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Title of host publication | Translational Neuroimmunology in Multiple Sclerosis |
Subtitle of host publication | From Disease Mechanisms to Clinical Applications |
Publisher | Elsevier Inc. |
Pages | 457-473 |
Number of pages | 17 |
ISBN (Electronic) | 9780128020074 |
ISBN (Print) | 9780128019146 |
DOIs | |
State | Published - 3 Aug 2016 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2016 Elsevier Inc. All rights reserved.
Keywords
- Antibodies
- Antiergotype
- Antiidiotype
- Autoimmunity
- Cell therapy
- T cells
- T-cell vaccination