TAF7L modulates brown adipose tissue formation

Haiying Zhou, Bo Wan, Ivan Grubisic, Tommy Kaplan, Robert Tjian

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Brown adipose tissue (BAT) plays an essential role in metabolic homeostasis by dissipating energy via thermogenesis through uncoupling protein 1 (UCP1). Previously, we reported that the TATA-binding protein associated factor 7L (TAF7L) is an important regulator of white adipose tissue (WAT) differentiation. Here, we show that TAF7L also serves as a molecular switch between brown fat and muscle lineages in vivo and in vitro. In adipose tissue, TAF7L-containing TFIID complexes associate with PPARγ to mediate DNA looping between distal enhancers and core promoter elements. Our findings suggest that presence of the tissue-specific TAF7L subunit in TFIID functions to promote long-range chromatin interactions during BAT lineage specification.

Original languageAmerican English
Article numbere02811
JournaleLife
Volume2014
Issue number3
DOIs
StatePublished - 29 Mar 2014

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