Abstract
Noncovalent interactions are the main driving force in the folding of proteins into a 3D functional structure. Motivated by the wish to reveal the mechanisms of the associated self-assembly processes, scientists are focusing on studying self-assembly processes of short protein segments (peptides). While this research has led to major advances in the understanding of biological and pathological process, only in recent years has the applicative potential of the resulting self-assembled peptide assemblies started to be explored. Here, major advances in the development of biomimetic supramolecular peptide assemblies as coatings, gels, and as electroactive materials, are highlighted. The guiding lines for the design of helical peptides, β strand peptides, as well as surface binding monolayer-forming peptides that can be utilized for a specific function are highlighted. Examples of their applications in diverse immerging applications in, e.g., ecology, biomedicine, and electronics, are described. Taking into account that, in addition to extraordinary design flexibility, these materials are naturally biocompatible and ecologically friendly, and their production is cost effective, the emergence of devices incorporating these biomimetic materials in the market is envisioned in the near future.
Original language | American English |
---|---|
Article number | 1707083 |
Journal | Advanced Materials |
Volume | 30 |
Issue number | 41 |
DOIs | |
State | Published - 11 Oct 2018 |
Bibliographical note
Funding Information:M.A. is a recipient of the postdoctoral fellowship for women scientists from the Planning and Budgeting Committee, the Council for Higher Education, Israel. S.Y. acknowledges the Clore Foundation for financial support. The authors thank the support by the European Research Council BISON project (E.G.) and N.A. acknowledges support by Grant No. 2015673 from the United States–Israel Binational Science Foundation (BSF), joint grant with the United States National Science Foundation (NSF).
Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Keywords
- bioelectronics
- hydrogels
- nanostructures
- peptides
- self-assembly