TY - JOUR
T1 - TAM receptors and the clearance of apoptotic cells
AU - Lemke, Greg
AU - Burstyn-Cohen, Tal
PY - 2010/10
Y1 - 2010/10
N2 - The Tyro3, Axl, and Mer (TAM) receptor tyrosine kinases and their ligands Gas6 and Protein S are required for the optimal phagocytosis of apoptotic cells in the mature immune, nervous, and reproductive systems. Genetic analyses in mice, rats, and humans reveal that this receptor-ligand system plays an especially important role in the phagocytosis that is triggered by the "eat-me" signal phosphatidylserine. Deficiencies in TAM signaling lead to human retinal dystrophies and may contribute to lupus and other human autoimmune diseases. The TAM system appears to interact and cooperate with several other phagocytic networks, including scavenger receptor and integrin-based systems, and may serve as a signaling hub that integrates these systems.
AB - The Tyro3, Axl, and Mer (TAM) receptor tyrosine kinases and their ligands Gas6 and Protein S are required for the optimal phagocytosis of apoptotic cells in the mature immune, nervous, and reproductive systems. Genetic analyses in mice, rats, and humans reveal that this receptor-ligand system plays an especially important role in the phagocytosis that is triggered by the "eat-me" signal phosphatidylserine. Deficiencies in TAM signaling lead to human retinal dystrophies and may contribute to lupus and other human autoimmune diseases. The TAM system appears to interact and cooperate with several other phagocytic networks, including scavenger receptor and integrin-based systems, and may serve as a signaling hub that integrates these systems.
KW - Apoptosis
KW - Gas6
KW - Protein S
KW - TAM receptors
KW - Tyrosine kinase
UR - http://www.scopus.com/inward/record.url?scp=78049499991&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2010.05744.x
DO - 10.1111/j.1749-6632.2010.05744.x
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C2 - 20958312
AN - SCOPUS:78049499991
SN - 0077-8923
VL - 1209
SP - 23
EP - 29
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
IS - 1
ER -
