Tandem catalytic condensation and hydrogenation processes in ionic liquids

Mubeen Baidossi; Asutosh V. Joshi; Sudip Mukhopadhyay; Yoel Sasson

doi:10.1016/j.tetlet.2005.01.092

Tandem catalytic condensation and hydrogenation processes in ionic liquids

Mubeen Baidossi, Asutosh V. Joshi, Sudip Mukhopadhyay, Yoel Sasson^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A domino reaction composed of a Knoevenagel condensation combined with a simultaneous catalytic hydrogenation is reported in an ionic liquid solvent under mild conditions (298-363 K and 300 kPa). No interference between the catalysts (Pd/C and amine acetate salt) of the two diverse steps was monitored. The product could be neatly extracted by diethyl ether and the solvent containing the catalysts could be recycled and reused five times without any loss in activity or selectivity. The same methodology in a common organic solvent such as DMA resulted in significant competing parallel hydrogenation of the aldehyde to alcohol.

Original language	English
Pages (from-to)	1885-1887
Number of pages	3
Journal	Tetrahedron Letters
Volume	46
Issue number	11
DOIs	https://doi.org/10.1016/j.tetlet.2005.01.092
State	Published - 14 Mar 2005

Keywords

Hydrogenation
Ionic liquids
Knoevenagel condensation
Pd/C

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title = "Tandem catalytic condensation and hydrogenation processes in ionic liquids",

abstract = "A domino reaction composed of a Knoevenagel condensation combined with a simultaneous catalytic hydrogenation is reported in an ionic liquid solvent under mild conditions (298-363 K and 300 kPa). No interference between the catalysts (Pd/C and amine acetate salt) of the two diverse steps was monitored. The product could be neatly extracted by diethyl ether and the solvent containing the catalysts could be recycled and reused five times without any loss in activity or selectivity. The same methodology in a common organic solvent such as DMA resulted in significant competing parallel hydrogenation of the aldehyde to alcohol.",

keywords = "Hydrogenation, Ionic liquids, Knoevenagel condensation, Pd/C",

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AU - Baidossi, Mubeen

AU - Joshi, Asutosh V.

AU - Mukhopadhyay, Sudip

AU - Sasson, Yoel

PY - 2005/3/14

Y1 - 2005/3/14

N2 - A domino reaction composed of a Knoevenagel condensation combined with a simultaneous catalytic hydrogenation is reported in an ionic liquid solvent under mild conditions (298-363 K and 300 kPa). No interference between the catalysts (Pd/C and amine acetate salt) of the two diverse steps was monitored. The product could be neatly extracted by diethyl ether and the solvent containing the catalysts could be recycled and reused five times without any loss in activity or selectivity. The same methodology in a common organic solvent such as DMA resulted in significant competing parallel hydrogenation of the aldehyde to alcohol.

AB - A domino reaction composed of a Knoevenagel condensation combined with a simultaneous catalytic hydrogenation is reported in an ionic liquid solvent under mild conditions (298-363 K and 300 kPa). No interference between the catalysts (Pd/C and amine acetate salt) of the two diverse steps was monitored. The product could be neatly extracted by diethyl ether and the solvent containing the catalysts could be recycled and reused five times without any loss in activity or selectivity. The same methodology in a common organic solvent such as DMA resulted in significant competing parallel hydrogenation of the aldehyde to alcohol.

KW - Hydrogenation

KW - Ionic liquids

KW - Knoevenagel condensation

KW - Pd/C

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VL - 46

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JO - Tetrahedron Letters

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Tandem catalytic condensation and hydrogenation processes in ionic liquids

Abstract

Keywords

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