Tandem silica gel-catalysed rearrangements and subsequent Baeyer-Villiger reactions of artemisinin derivatives

Boris Yagen, Yu Ming Pu, Herman J.C. Yen, Herman Ziffer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Novel silica gel-catalysed reactions of dihydroartemisinin 1b to deoxyartemisinin 11 and 11 β-hydroxy-11-epidihydroartemisinin 8 to compound 9 under mild conditions are described. The structures of the products were determined by mass spectrometry and 1D- and 2D-NMR spectroscopy. A mechanism for their formation is proposed.

Original languageEnglish
Pages (from-to)843-846
Number of pages4
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number7
DOIs
StatePublished - 1994

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