Tandem silica gel-catalysed rearrangements and subsequent Baeyer-Villiger reactions of artemisinin derivatives

Boris Yagen; Yu Ming Pu; Herman J.C. Yen; Herman Ziffer

doi:10.1039/p19940000843

Tandem silica gel-catalysed rearrangements and subsequent Baeyer-Villiger reactions of artemisinin derivatives

Boris Yagen
, Yu Ming Pu
, Herman J.C. Yen
, Herman Ziffer^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Novel silica gel-catalysed reactions of dihydroartemisinin 1b to deoxyartemisinin 11 and 11 β-hydroxy-11-epidihydroartemisinin 8 to compound 9 under mild conditions are described. The structures of the products were determined by mass spectrometry and 1D- and 2D-NMR spectroscopy. A mechanism for their formation is proposed.

Original language	English
Pages (from-to)	843-846
Number of pages	4
Journal	Journal of the Chemical Society, Perkin Transactions 1
Issue number	7
DOIs	https://doi.org/10.1039/p19940000843
State	Published - 1994

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title = "Tandem silica gel-catalysed rearrangements and subsequent Baeyer-Villiger reactions of artemisinin derivatives",

abstract = "Novel silica gel-catalysed reactions of dihydroartemisinin 1b to deoxyartemisinin 11 and 11 β-hydroxy-11-epidihydroartemisinin 8 to compound 9 under mild conditions are described. The structures of the products were determined by mass spectrometry and 1D- and 2D-NMR spectroscopy. A mechanism for their formation is proposed.",

author = "Boris Yagen and Pu, \{Yu Ming\} and Yen, \{Herman J.C.\} and Herman Ziffer",

year = "1994",

doi = "10.1039/p19940000843",

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pages = "843--846",

journal = "Journal of the Chemical Society, Perkin Transactions 1",

issn = "1472-7781",

publisher = "Royal Society of Chemistry",

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T1 - Tandem silica gel-catalysed rearrangements and subsequent Baeyer-Villiger reactions of artemisinin derivatives

AU - Yagen, Boris

AU - Pu, Yu Ming

AU - Yen, Herman J.C.

AU - Ziffer, Herman

PY - 1994

Y1 - 1994

N2 - Novel silica gel-catalysed reactions of dihydroartemisinin 1b to deoxyartemisinin 11 and 11 β-hydroxy-11-epidihydroartemisinin 8 to compound 9 under mild conditions are described. The structures of the products were determined by mass spectrometry and 1D- and 2D-NMR spectroscopy. A mechanism for their formation is proposed.

AB - Novel silica gel-catalysed reactions of dihydroartemisinin 1b to deoxyartemisinin 11 and 11 β-hydroxy-11-epidihydroartemisinin 8 to compound 9 under mild conditions are described. The structures of the products were determined by mass spectrometry and 1D- and 2D-NMR spectroscopy. A mechanism for their formation is proposed.

UR - https://www.scopus.com/pages/publications/37049079189

U2 - 10.1039/p19940000843

DO - 10.1039/p19940000843

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AN - SCOPUS:37049079189

SN - 1472-7781

SP - 843

EP - 846

JO - Journal of the Chemical Society, Perkin Transactions 1

JF - Journal of the Chemical Society, Perkin Transactions 1

IS - 7

ER -

Tandem silica gel-catalysed rearrangements and subsequent Baeyer-Villiger reactions of artemisinin derivatives

Abstract

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