TY - JOUR
T1 - Targeting hepatic glucose metabolism in the treatment of type 2 diabetes
AU - Rines, Amy K.
AU - Sharabi, Kfir
AU - Tavares, Clint D.J.
AU - Puigserver, Pere
N1 - Publisher Copyright:
© 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Type 2 diabetes mellitus is characterized by the dysregulation of glucose homeostasis, resulting in hyperglycaemia. Although current diabetes treatments have exhibited some success in lowering blood glucose levels, their effect is not always sustained and their use may be associated with undesirable side effects, such as hypoglycaemia. Novel antidiabetic drugs, which may be used in combination with existing therapies, are therefore needed. The potential of specifically targeting the liver to normalize blood glucose levels has not been fully exploited. Here, we review the molecular mechanisms controlling hepatic gluconeogenesis and glycogen storage, and assess the prospect of therapeutically targeting associated pathways to treat type 2 diabetes.
AB - Type 2 diabetes mellitus is characterized by the dysregulation of glucose homeostasis, resulting in hyperglycaemia. Although current diabetes treatments have exhibited some success in lowering blood glucose levels, their effect is not always sustained and their use may be associated with undesirable side effects, such as hypoglycaemia. Novel antidiabetic drugs, which may be used in combination with existing therapies, are therefore needed. The potential of specifically targeting the liver to normalize blood glucose levels has not been fully exploited. Here, we review the molecular mechanisms controlling hepatic gluconeogenesis and glycogen storage, and assess the prospect of therapeutically targeting associated pathways to treat type 2 diabetes.
UR - http://www.scopus.com/inward/record.url?scp=84981489539&partnerID=8YFLogxK
U2 - 10.1038/nrd.2016.151
DO - 10.1038/nrd.2016.151
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C2 - 27516169
AN - SCOPUS:84981489539
SN - 1474-1776
VL - 15
SP - 786
EP - 804
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
IS - 11
ER -
