Targeting metabolic pathways for genetic engineering abiotic stress-tolerance in crops

Maria Reguera, Zvi Peleg, Eduardo Blumwald*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

118 Scopus citations


Abiotic stress conditions are the major limitations in modern agriculture. Although many genes associated with plant response(s) to abiotic stresses have been indentified and used to generate stress tolerant plants, the success in producing stress-tolerant crops is limited. New technologies are providing opportunities to generate stress tolerant crops. Biotechnological approaches that emphasize the development of transgenic crops under conditions that mimic the field situation and focus on the plant reproductive stage will significantly improve the opportunities of producing stress tolerant crops. Here, we highlight recent advances and discuss the limitations that hinder the fast integration of transgenic crops into agriculture and suggest possible research directions. This article is part of a Special Issue entitled: Plant gene regulation in response to abiotic stress.

Original languageAmerican English
Pages (from-to)186-194
Number of pages9
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Issue number2
StatePublished - Feb 2012
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by grant from NSF-IOS-0802112 , CGIAR GCP#3008.03 , UC Discovery #bio06-10627 , and the Will W. Lester Endowment of University of California . Z.P. was supported by Vaadia-BARD postdoctoral Fellowship Award No. FI-419-08 from the United States–Israel Binational Agricultural Research and Development Fund (BARD) .


  • Abiotic stress
  • Genetic engineering crops
  • Stress combination
  • Stress-tolerance
  • Yield


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