Taste GPCRs and their ligands

Nitzan Dubovski, Fabrizio Fierro, Eitan Margulis, Yaron Ben Shoshan-Galeczki, Lior Peri, Masha Y. Niv*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


Taste GPCRs are expressed in taste buds on the tongue and play a key role in food choice and consumption. They are also expressed extra-orally, with various physiological roles that are currently under study. Unraveling the roles of these receptors relies on the knowledge of their ligands. Combining sensory, cell-based and computational approaches enabled the discovery of numerous agonists and several antagonists. Here we provide a short overview of taste receptor families, main recent methods for ligands discovery, and current sources of information about known ligands. The future directions that are likely to impact the taste GPCR field include focus on ligand interactions with naturally occurring polymorphisms, as well as harnessing the power of CryoEM and of multiple signaling readout techniques.

Original languageAmerican English
Title of host publicationG Protein-Coupled Receptors - Part A
EditorsArun K. Shukla
PublisherElsevier B.V.
Number of pages17
ISBN (Print)9780323994316
StatePublished - Jan 2022

Publication series

NameProgress in Molecular Biology and Translational Science
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

Bibliographical note

Funding Information:
All figures were created with BioRender.com.

Publisher Copyright:
© 2022 Elsevier Inc.


  • Agonist
  • Antagonist
  • Computational
  • Family A
  • Family C
  • Functional assays
  • GPCR
  • Machine-learning
  • Receptor
  • Taste


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