TY - JOUR
T1 - Tat for enzyme/protein delivery to restore or destroy cell activity in human diseases
AU - Lichtenstein, Michal
AU - Zabit, Samar
AU - Hauser, Noa
AU - Farouz, Sarah
AU - Melloul, Orly
AU - Hirbawi, Joud
AU - Lorberboum-Galski, Haya
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/9/6
Y1 - 2021/9/6
N2 - Much effort has been dedicated in the recent decades to find novel protein/enzyme-based therapies for human diseases, the major challenge of such therapies being the intracellular delivery and reaching sub-cellular organelles. One promising approach is the use of cell-penetrating peptides (CPPs) for delivering enzymes/proteins into cells. In this review, we describe the potential therapeutic usages of CPPs (mainly trans-activator of transcription protein, TAT) in enabling the uptake of biologically active proteins/enzymes needed in cases of protein/enzyme deficiency, concentrating on mitochondrial diseases and on the import of enzymes or peptides in order to destroy pathogenic cells, focusing on cancer cells.
AB - Much effort has been dedicated in the recent decades to find novel protein/enzyme-based therapies for human diseases, the major challenge of such therapies being the intracellular delivery and reaching sub-cellular organelles. One promising approach is the use of cell-penetrating peptides (CPPs) for delivering enzymes/proteins into cells. In this review, we describe the potential therapeutic usages of CPPs (mainly trans-activator of transcription protein, TAT) in enabling the uptake of biologically active proteins/enzymes needed in cases of protein/enzyme deficiency, concentrating on mitochondrial diseases and on the import of enzymes or peptides in order to destroy pathogenic cells, focusing on cancer cells.
KW - Apoptosis
KW - CPPs
KW - Cancer
KW - MTS
KW - Mitochondrial diseases
KW - TAT
KW - TAT-ApoProtein fusion proteins
KW - TAT-MTS-MitoProtein fusion proteins
UR - http://www.scopus.com/inward/record.url?scp=85114832394&partnerID=8YFLogxK
U2 - 10.3390/life11090924
DO - 10.3390/life11090924
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C2 - 34575072
AN - SCOPUS:85114832394
SN - 2075-1729
VL - 11
JO - Life
JF - Life
IS - 9
M1 - 924
ER -
