TAT-mediated delivery of LAD restores pyruvate dehydrogenase complex activity in the mitochondria of patients with LAD deficiency

Keyphrases

• Mitochondria 100%
• Transcriptional Repressor 100%
• Lipoamide Dehydrogenase 100%
• Pyruvate Dehydrogenase Complex 100%
• Dehydrogenase Deficiency 100%
• Enzymatic Complex 20%
• Mitochondrial Disease 20%
• Amino Acids 10%
• Carbohydrate Metabolism 10%
• Mitochondrial Matrix 10%
• Biological Membranes 10%
• Metabolic Disorders 10%
• Modern Medicine 10%
• Dehydrogenase Activity 10%
• Enzyme Replacement Therapy 10%
• Enzyme Deficiency 10%
• α-keto Acids 10%
• Endogenous Enzymes 10%
• Dehydrogenase Complex 10%
• Transactivator of Transcription Peptide 10%

Biochemistry, Genetics and Molecular Biology

• Mitochondrion 100%
• Transcription 100%
• Dihydrolipoamide Dehydrogenase 100%
• Pyruvate Dehydrogenase Complex 100%
• Enzyme 30%
• Amino Acids 10%
• Metabolic Pathway 10%
• Oxidoreductase 10%
• Normal Value 10%
• Mitochondrial Matrix 10%
• Dehydrogenase 10%
• Biomembrane 10%
• Metabolic Disorder 10%
• Mitochondrial Disorder 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Pyruvate Dehydrogenase Complex 100%
• Dihydrolipoamide Dehydrogenase 100%
• Disorders of Mitochondrial Functions 20%
• Amino Acid 10%
• Metabolic Disorder 10%
• Oxidoreductase 10%
• Replacement Therapy 10%
• Enzyme Deficiency 10%
• Oxoacid 10%