Telocytes in the Luminal GI Tract

Michal Shoshkes-Carmel*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Telocytes are unique mesenchymal cells characterized by multiple remarkably long cytoplasmic extensions that extend hundreds of micron away from the cell body. Through these extensions, telocytes establish a 3-dimensional network by connecting with other telocytes and various cell types within the tissue. In the intestine, telocytes have emerged as an essential component of the stem cell niche, providing Wnt proteins that are critical for the proliferation of stem and progenitor cells. However, the analysis of single-cell RNA sequencing has revealed other stromal populations and mechanisms for niche organization, raising questions about the role of telocytes as a component of the stem cell niche. This review explores the current state-of-the-art, existing controversies, and potential future directions related to telocytes in the luminal gastrointestinal tract.

Original languageAmerican English
Pages (from-to)697-701
Number of pages5
Issue number5
StatePublished - Jan 2024

Bibliographical note

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  • Intestinal homeostasis
  • Stem-cell niche
  • Stroma


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