Abstract
The effects of cytochalasin B on the antigen recognition process have been examined using an in vitro assay of macrophage inhibition factor (MIF) production by activated guinea pig T lymphocyte enriched populations. The data indicate that cytochalasin B inhibits MIF production if added at the initiation of culture but not if added 2 hr after antigen. These data are interpreted as consistent with either an inhibition by cytochalasin B of the physical association of antigen bearing macrophage and lymphocytes or with an inhibition of the access of antigen to the T lymphocyte receptor.
Original language | English |
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Pages (from-to) | 1140-1142 |
Number of pages | 3 |
Journal | Journal of Immunology |
Volume | 115 |
Issue number | 4 |
State | Published - 1975 |
Externally published | Yes |