Ten-year results of the randomized control trials of coronary artery bypass graft surgery: tabular data compiled by the collaborative effort of the original trial investigators. Part 2 of 2.

S. Yusuf*, D. Zucker, T. C. Chalmers

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

This metaanalysis has some important general implications for conducting studies to evaluate other treatments as well as for patient management. To avoid missing clinically important differences (eg, 15-20% differences in mortality at 5 years) between the methods of revascularization, study populations should be several times larger than those in our metaanalysis, should include a high proportion of the types of patients for whom surgery is known to be superior to medical therapy, and should be complemented by a systematic overview. We recommend that researchers running large randomized trials consider prospective collaboration with researchers from other trials with a common protocol.

Original languageAmerican English
Pages (from-to)[3987 words; 31 paragraphs]
JournalThe Online journal of current clinical trials
VolumeDoc No 144
StatePublished - 15 Oct 1994
Externally publishedYes

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