TY - JOUR
T1 - Testing a degradable topical varnish of cetylpyridinium chloride in an experimental dental biofilm model
AU - Steinberg, Doron
AU - Moldovan, Meir
AU - Molukandov, David
PY - 2001
Y1 - 2001
N2 - Dental biofilms are highly associated with the development of dental caries. Novel drug delivery systems are being developed in order to eliminate cariogenic bacteria from the dental biofilms. We formulated two degradable sustained release varnishes, based on acrylic resin, with cetylpyridinium chloride (CPC) as the active agent. These formulations were tested in a dental biofilm model. The retention of CPC in the biofilm was dependent upon the pharmaceutical additives of the varnish. Both varnishes decreased bacterial adhesion, while also demonstrating marked antibacterial properties against the bacteria in the biofilm.
AB - Dental biofilms are highly associated with the development of dental caries. Novel drug delivery systems are being developed in order to eliminate cariogenic bacteria from the dental biofilms. We formulated two degradable sustained release varnishes, based on acrylic resin, with cetylpyridinium chloride (CPC) as the active agent. These formulations were tested in a dental biofilm model. The retention of CPC in the biofilm was dependent upon the pharmaceutical additives of the varnish. Both varnishes decreased bacterial adhesion, while also demonstrating marked antibacterial properties against the bacteria in the biofilm.
UR - http://www.scopus.com/inward/record.url?scp=0034884426&partnerID=8YFLogxK
U2 - 10.1093/jac/48.2.241
DO - 10.1093/jac/48.2.241
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C2 - 11481295
AN - SCOPUS:0034884426
SN - 0305-7453
VL - 48
SP - 241
EP - 243
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
IS - 2
ER -