Tetrachloroethylene exposure and risk of schizophrenia: Offspring of dry cleaners in a population birth cohort, preliminary findings

Mary C. Perrin; Mark G. Opler; Susan Harlap; Jill Harkavy-Friedman; Karine Kleinhaus; Daniella Nahon; Shmuel Fennig; Ezra S. Susser; Dolores Malaspina

doi:10.1016/j.schres.2006.09.024

Tetrachloroethylene exposure and risk of schizophrenia: Offspring of dry cleaners in a population birth cohort, preliminary findings

Mary C. Perrin^*, Mark G. Opler, Susan Harlap, Jill Harkavy-Friedman, Karine Kleinhaus, Daniella Nahon, Shmuel Fennig, Ezra S. Susser, Dolores Malaspina

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Tetrachloroethylene is a solvent used in dry cleaning with reported neurotoxic effects. Using proportional hazard methods, we examined the relationship between parental occupation as a dry cleaner and risk for schizophrenia in a prospective population-based cohort of 88,829 offspring born in Jerusalem from 1964 through 1976, followed from birth to age 21-33 years. Of 144 offspring whose parents were dry cleaners, 4 developed schizophrenia. We observed an increased incidence of schizophrenia in offspring of parents who were dry cleaners (RR = 3.4, 95% CI, 1.3-9.2, p = 0.01). Tetrachloroethylene exposure warrants further investigation as a risk factor for schizophrenia.

Original language	English
Pages (from-to)	251-254
Number of pages	4
Journal	Schizophrenia Research
Volume	90
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2006.09.024
State	Published - Feb 2007
Externally published	Yes

Keywords

Dry cleaning
Perc
Perchloroethylene
Schizophrenia
Tetrachloroethylene

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10.1016/j.schres.2006.09.024

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title = "Tetrachloroethylene exposure and risk of schizophrenia: Offspring of dry cleaners in a population birth cohort, preliminary findings",

abstract = "Tetrachloroethylene is a solvent used in dry cleaning with reported neurotoxic effects. Using proportional hazard methods, we examined the relationship between parental occupation as a dry cleaner and risk for schizophrenia in a prospective population-based cohort of 88,829 offspring born in Jerusalem from 1964 through 1976, followed from birth to age 21-33 years. Of 144 offspring whose parents were dry cleaners, 4 developed schizophrenia. We observed an increased incidence of schizophrenia in offspring of parents who were dry cleaners (RR = 3.4, 95% CI, 1.3-9.2, p = 0.01). Tetrachloroethylene exposure warrants further investigation as a risk factor for schizophrenia.",

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AU - Opler, Mark G.

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AU - Harkavy-Friedman, Jill

AU - Kleinhaus, Karine

AU - Nahon, Daniella

AU - Fennig, Shmuel

AU - Susser, Ezra S.

AU - Malaspina, Dolores

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Tetrachloroethylene exposure and risk of schizophrenia: Offspring of dry cleaners in a population birth cohort, preliminary findings

Abstract

Keywords

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