TY - JOUR
T1 - Tetrachloroethylene exposure and risk of schizophrenia
T2 - Offspring of dry cleaners in a population birth cohort, preliminary findings
AU - Perrin, Mary C.
AU - Opler, Mark G.
AU - Harlap, Susan
AU - Harkavy-Friedman, Jill
AU - Kleinhaus, Karine
AU - Nahon, Daniella
AU - Fennig, Shmuel
AU - Susser, Ezra S.
AU - Malaspina, Dolores
PY - 2007/2
Y1 - 2007/2
N2 - Tetrachloroethylene is a solvent used in dry cleaning with reported neurotoxic effects. Using proportional hazard methods, we examined the relationship between parental occupation as a dry cleaner and risk for schizophrenia in a prospective population-based cohort of 88,829 offspring born in Jerusalem from 1964 through 1976, followed from birth to age 21-33 years. Of 144 offspring whose parents were dry cleaners, 4 developed schizophrenia. We observed an increased incidence of schizophrenia in offspring of parents who were dry cleaners (RR = 3.4, 95% CI, 1.3-9.2, p = 0.01). Tetrachloroethylene exposure warrants further investigation as a risk factor for schizophrenia.
AB - Tetrachloroethylene is a solvent used in dry cleaning with reported neurotoxic effects. Using proportional hazard methods, we examined the relationship between parental occupation as a dry cleaner and risk for schizophrenia in a prospective population-based cohort of 88,829 offspring born in Jerusalem from 1964 through 1976, followed from birth to age 21-33 years. Of 144 offspring whose parents were dry cleaners, 4 developed schizophrenia. We observed an increased incidence of schizophrenia in offspring of parents who were dry cleaners (RR = 3.4, 95% CI, 1.3-9.2, p = 0.01). Tetrachloroethylene exposure warrants further investigation as a risk factor for schizophrenia.
KW - Dry cleaning
KW - Perc
KW - Perchloroethylene
KW - Schizophrenia
KW - Tetrachloroethylene
UR - https://www.scopus.com/pages/publications/33846575118
U2 - 10.1016/j.schres.2006.09.024
DO - 10.1016/j.schres.2006.09.024
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C2 - 17113267
AN - SCOPUS:33846575118
SN - 0920-9964
VL - 90
SP - 251
EP - 254
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -