TY - JOUR
T1 - Tetrahydrocannabinol and endocannabinoids in feeding and appetite
AU - Berry, Elliot M.
AU - Mechoulam, Raphael
PY - 2002/8
Y1 - 2002/8
N2 - The physiological control of appetite and satiety, in which numerous neurotransmitters and neuropeptides play a role, is extremely complex. Here we describe the involvement of endocannabinoids in these processes. These endogenous neuromodulators enhance appetite in animals. The same effect is observed in animals and in humans with the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol, which is an approved appetite-enhancing drug. The CB1 cannabinoid receptor antagonist SR141716A blocks the effects on feeding produced by the endocannabinoids. If administered to mice pups, this antagonist blocks suckling. In obese humans, it causes weight reduction. Very little is known about the physiological and biochemical mechanisms involved in the effects of Δ9-tetrahydrocannabinol and the cannabinoids in feeding and appetite.
AB - The physiological control of appetite and satiety, in which numerous neurotransmitters and neuropeptides play a role, is extremely complex. Here we describe the involvement of endocannabinoids in these processes. These endogenous neuromodulators enhance appetite in animals. The same effect is observed in animals and in humans with the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol, which is an approved appetite-enhancing drug. The CB1 cannabinoid receptor antagonist SR141716A blocks the effects on feeding produced by the endocannabinoids. If administered to mice pups, this antagonist blocks suckling. In obese humans, it causes weight reduction. Very little is known about the physiological and biochemical mechanisms involved in the effects of Δ9-tetrahydrocannabinol and the cannabinoids in feeding and appetite.
KW - 2-Arachidonoylglycerol
KW - Anandamide
KW - Cannabinoid receptors
KW - Leptin
KW - SR141716A
KW - Suckling
UR - http://www.scopus.com/inward/record.url?scp=0036669295&partnerID=8YFLogxK
U2 - 10.1016/S0163-7258(02)00257-7
DO - 10.1016/S0163-7258(02)00257-7
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 12182965
AN - SCOPUS:0036669295
SN - 0163-7258
VL - 95
SP - 185
EP - 190
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
IS - 2
ER -