The achilles heel of ErbB-2/HER2: regulation by the Hsp90 chaperone machine and potential for pharmacological intervention.

Keyphrases

• Human Epidermal Growth Factor Receptor 2 (HER2) 100%
• ErbB2 100%
• Achilles Heel 100%
• Pharmacological Intervention 100%
• Heat Shock Protein 90 (Hsp90) 100%
• Chaperone Hsp90 100%
• ErbB 71%
• Signal Transduction 28%
• ErbB Signaling 28%
• Tyrosine Kinase Inhibitor 14%
• Malignancy 14%
• Tyrosine Kinase Activity 14%
• ErbB1 14%
• Chaperone 14%
• Co-chaperone 14%
• Multiple Mechanisms 14%
• Tumor Cell Proliferation 14%
• EGF Receptor 14%
• Clinical Trials 14%
• Receptor Tyrosine Kinase 14%
• Receptor 2 14%
• Signaling Network 14%
• Mature Form 14%
• Kinase Domain 14%
• Epithelial Tissue 14%
• Epithelial Origin 14%
• System Control 14%
• Akt PKB 14%
• Downstream Effectors 14%
• Potential Therapeutic Strategies 14%
• Aberrant Signaling 14%
• RAF1 14%
• Chaperone Function 14%
• Degradation Pathway 14%
• Recognition Motif 14%
• Chaperone System 14%
• Window of Opportunity 14%
• HER Receptors 14%
• Cancer Clinical Trials 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Protein Tyrosine Kinase 100%
• Malignant Neoplasm 100%
• Epidermal Growth Factor Receptor 100%
• Chaperone 100%
• Tumor Growth 50%
• Protein Tyrosine Kinase Inhibitor 50%
• Receptor 50%
• Clinical Trial 50%
• Phosphotransferase 50%

Biochemistry, Genetics and Molecular Biology

• ErbB 100%
• Hsp90 100%
• Signal Transduction 15%
• Receptor Tyrosine Kinase 15%
• Epidermal Growth Factor Receptor 15%
• Phosphotransferase 7%
• Kinase 7%
• Tumor Progression 7%
• Tyrosine Kinase 7%
• Clinical Trial 7%
• Tyrosine Kinase Inhibitor 7%