The addition of avibactam renders piperacillin an effective treatment for Mycobacterium abscessus infection in an in vivo model

Michal Meir, Pablo Bifani, Daniel Barkan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Treating M. abscessus infection is challenging due to the potent β-lactamase Bla Mab (Beta-lactamase of M. abscessus ) . Avibactam is a non-β-lactam, β-lactamase inhibitor shown to inhibit Bla Mab . We tested whether avibactem can render piperacillin effective against M. Abscessus. In-vitro, avibactam enhanced the activity of piperacillin by 16-32 fold, with no significant effect on meropenem. In an in-vivo Galleria mellonella model, meropenem and piperacillin/avibactam significantly decreased infection burden compared to untreated controls. Neither piperacillin nor avibactam alone had a significant effect.

Original languageAmerican English
Article number151
JournalAntimicrobial Resistance and Infection Control
Volume7
Issue number1
DOIs
StatePublished - 13 Dec 2018

Bibliographical note

Publisher Copyright:
© 2018 The Author(s).

Keywords

  • Avibactam
  • Combination treatment
  • MIC
  • Mycobacterium abscessus
  • Piperacillin

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