The advantage of being a low responder

Irun R. Cohen*, Daniel M. Altmann, Aharon Friedman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Immune response genes determine the magnitude of many immune responses. A low response is often ascribed to a genetic defect. Here Irun Cohen argues that a poor response instead reflects a heightened sensitivity to the conditions in which antigen is encountered. When these are optimal the response is normal. Poor responders thus have the advantage of a greater fexibility of response over individuals who respond strongly regardless of prevailing circumstances.

Original languageEnglish
Pages (from-to)147-148
Number of pages2
JournalImmunology Today
Volume6
Issue number5
DOIs
StatePublished - May 1985
Externally publishedYes

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