The African turquoise killifish: A model for exploring vertebrate aging and diseases in the fast lane

Itamar Harel, Anne Brunet*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

23 Scopus citations

Abstract

Why and how organisms age remains a mystery, and it defines one of the biggest challenges in biology. Aging is also the primary risk factor for many human pathologies, such as cancer, diabetes, cardiovascular diseases, and neurodegenerative diseases. Thus, manipulating the aging rate and potentially postponing the onset of these devastating diseases could have a tremendous impact on human health. Recent studies, relying primarily on nonvertebrate short-lived model systems, have shown the importance of both genetic and environmental factors in modulating the aging rate. However, relatively little is known about aging in vertebrates or what processes may be unique and specific to these complex organisms. Here we discuss how advances in genomics and genome editing have significantly expanded our ability to probe the aging process in a vertebrate system. We highlight recent findings from a naturally short-lived vertebrate, the African turquoise killifish, which provides an attractive platform for exploring mechanisms underlying vertebrate aging and age-related diseases.

Original languageAmerican English
Title of host publication21st Century Genetics Genes at Work, 2015
EditorsTerri Grodzicker, Bruce Stillman, David Stewart
PublisherCold Spring Harbor Laboratory Press
Pages275-279
Number of pages5
ISBN (Print)9781621821472
DOIs
StatePublished - 2016
Externally publishedYes
Event21st Century Genetics Genes at Work, 2015 - Huntington, United States
Duration: 26 May 201531 May 2015

Publication series

NameCold Spring Harbor Symposia on Quantitative Biology
Volume80
ISSN (Print)0091-7451
ISSN (Electronic)1943-4456

Conference

Conference21st Century Genetics Genes at Work, 2015
Country/TerritoryUnited States
CityHuntington
Period26/05/1531/05/15

Bibliographical note

Publisher Copyright:
© 2015 Cold Spring Harbor Laboratory Press.

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