TY - JOUR
T1 - The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan
AU - Valenzano, Dario Riccardo
AU - Benayoun, Bérénice A.
AU - Singh, Param Priya
AU - Zhang, Elisa
AU - Etter, Paul D.
AU - Hu, Chi Kuo
AU - Clément-Ziza, Mathieu
AU - Willemsen, David
AU - Cui, Rongfeng
AU - Harel, Itamar
AU - MacHado, Ben E.
AU - Yee, Muh Ching
AU - Sharp, Sabrina C.
AU - Bustamante, Carlos D.
AU - Beyer, Andreas
AU - Johnson, Eric A.
AU - Brunet, Anne
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/12/3
Y1 - 2015/12/3
N2 - Summary Lifespan is a remarkably diverse trait ranging from a few days to several hundred years in nature, but the mechanisms underlying the evolution of lifespan differences remain elusive. Here we de novo assemble a reference genome for the naturally short-lived African turquoise killifish, providing a unique resource for comparative and experimental genomics. The identification of genes under positive selection in this fish reveals potential candidates to explain its compressed lifespan. Several aging genes are under positive selection in this short-lived fish and long-lived species, raising the intriguing possibility that the same gene could underlie evolution of both compressed and extended lifespans. Comparative genomics and linkage analysis identify candidate genes associated with lifespan differences between various turquoise killifish strains. Remarkably, these genes are clustered on the sex chromosome, suggesting that short lifespan might have co-evolved with sex determination. Our study provides insights into the evolutionary forces that shape lifespan in nature.
AB - Summary Lifespan is a remarkably diverse trait ranging from a few days to several hundred years in nature, but the mechanisms underlying the evolution of lifespan differences remain elusive. Here we de novo assemble a reference genome for the naturally short-lived African turquoise killifish, providing a unique resource for comparative and experimental genomics. The identification of genes under positive selection in this fish reveals potential candidates to explain its compressed lifespan. Several aging genes are under positive selection in this short-lived fish and long-lived species, raising the intriguing possibility that the same gene could underlie evolution of both compressed and extended lifespans. Comparative genomics and linkage analysis identify candidate genes associated with lifespan differences between various turquoise killifish strains. Remarkably, these genes are clustered on the sex chromosome, suggesting that short lifespan might have co-evolved with sex determination. Our study provides insights into the evolutionary forces that shape lifespan in nature.
UR - http://www.scopus.com/inward/record.url?scp=84949184004&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2015.11.008
DO - 10.1016/j.cell.2015.11.008
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C2 - 26638078
AN - SCOPUS:84949184004
SN - 0092-8674
VL - 163
SP - 1539
EP - 1554
JO - Cell
JF - Cell
IS - 6
ER -