The antioxidant properties of thioctic acid: Characterization by cyclic voltammetry

S. Chevion*, M. Hofmann, R. Ziegler, M. Chevion, P. P. Nawroth

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Thioctic acid (TA) level and its antioxidant capacity were monitored by cyclic voltammetry (CV), in solution and in human plasma. A linear correlation between the anodic wave current Ia at 900 mV and [TA] was obtained. This indicates that TA, commonly found in human plasma, is an antioxidant component characterized by a potential E(1/2) = 900 mV and constitute, at least in part, the second anodic wave of the CV tracing. When plasma from diabetic patients was analyzed by CV, those patients under treatment with TA showed higher Ia than others not taking the drug. When the patients under treatment with TA were divided into groups according to the severity of their nephropathy, or according to the severity of their total complication count, Ia levels representing TA were significantly higher in those patients with more severe complications.

Original languageEnglish
Pages (from-to)317-327
Number of pages11
JournalBiochemistry and Molecular Biology International
Volume41
Issue number2
DOIs
StatePublished - Feb 1997

Keywords

  • Antioxidant capacity
  • Cyclic voltammetry
  • Diabetes mellitus
  • Method
  • Plasma
  • Thioctic acid

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