TY - JOUR
T1 - The antioxidant properties of thioctic acid
T2 - Characterization by cyclic voltammetry
AU - Chevion, S.
AU - Hofmann, M.
AU - Ziegler, R.
AU - Chevion, M.
AU - Nawroth, P. P.
PY - 1997/2
Y1 - 1997/2
N2 - Thioctic acid (TA) level and its antioxidant capacity were monitored by cyclic voltammetry (CV), in solution and in human plasma. A linear correlation between the anodic wave current Ia at 900 mV and [TA] was obtained. This indicates that TA, commonly found in human plasma, is an antioxidant component characterized by a potential E(1/2) = 900 mV and constitute, at least in part, the second anodic wave of the CV tracing. When plasma from diabetic patients was analyzed by CV, those patients under treatment with TA showed higher Ia than others not taking the drug. When the patients under treatment with TA were divided into groups according to the severity of their nephropathy, or according to the severity of their total complication count, Ia levels representing TA were significantly higher in those patients with more severe complications.
AB - Thioctic acid (TA) level and its antioxidant capacity were monitored by cyclic voltammetry (CV), in solution and in human plasma. A linear correlation between the anodic wave current Ia at 900 mV and [TA] was obtained. This indicates that TA, commonly found in human plasma, is an antioxidant component characterized by a potential E(1/2) = 900 mV and constitute, at least in part, the second anodic wave of the CV tracing. When plasma from diabetic patients was analyzed by CV, those patients under treatment with TA showed higher Ia than others not taking the drug. When the patients under treatment with TA were divided into groups according to the severity of their nephropathy, or according to the severity of their total complication count, Ia levels representing TA were significantly higher in those patients with more severe complications.
KW - Antioxidant capacity
KW - Cyclic voltammetry
KW - Diabetes mellitus
KW - Method
KW - Plasma
KW - Thioctic acid
UR - http://www.scopus.com/inward/record.url?scp=0031428902&partnerID=8YFLogxK
U2 - 10.1080/15216549700201331
DO - 10.1080/15216549700201331
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 9063572
AN - SCOPUS:0031428902
SN - 1039-9712
VL - 41
SP - 317
EP - 327
JO - Biochemistry and Molecular Biology International
JF - Biochemistry and Molecular Biology International
IS - 2
ER -