The Arabidopsis BELL1 and KNOX TALE homeodomain proteins interact through a domain conserved between plants and animals

M. Bellaoui, M. S. Pidkowich, A. Samach, K. Kushalappa, S. E. Kohalmi, Z. Modrusan, W. L. Crosby, G. W. Haughn*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

193 Scopus citations

Abstract

Interactions between TALE (three-amino acid loop extension) homeodomain proteins play important roles in the development of both fungi and animals. Although in plants, two different subclasses of TALE proteins include important developmental regulators, the existence of interactions between plant TALE proteins has remained unexplored. We have used the yeast two-hybrid system to demonstrate that the Arabidopsis BELL1 (BEL1) homeodomain protein can selectively heterodimerize with specific KNAT homeodomain proteins. Interaction is mediated by BEL1 sequences N terminal to the homeodomain and KNAT sequences including the MEINOX domain. These findings validate the hypothesis that the MEINOX domain has been conserved between plants and animals as an interaction domain for developmental regulators. In yeast, BEL1 and KNAT proteins can activate transcription only as a heterodimeric complex, suggesting a role for such complexes in planta. Finally, overlapping patterns of BEL1 and SHOOT MERISTEMLESS (STM) expression within the inflorescence meristem suggest a role for the BEL1-STM complex in maintaining the indeterminacy of the inflorescence meristem.

Original languageAmerican English
Pages (from-to)2455-2470
Number of pages16
JournalPlant Cell
Volume13
Issue number11
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Dive into the research topics of 'The Arabidopsis BELL1 and KNOX TALE homeodomain proteins interact through a domain conserved between plants and animals'. Together they form a unique fingerprint.

Cite this