The arotinoid Ro 40-8757 has antiproliferative effects in drug-resistant human colon and breast cancer cell lines in vitro

Christophe Louvet*, Sylvie Empereur, Dominique Fagot, Elisabeth Forgue-Lafitte, Eric Chastre, Amazia Zimber, Jan Mester, Christian Gespach

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We have examined the antiproliferative effects of the arotinoid Ro 40-8757 in 3 drug-resistant human adenocarcinoma cell lines: the colonic cells HT29-5FU and CaCo2, and the mammary cells MCF-7mdrl. Whereas all-trans retinoic acid had no effect at the concentration of 10-6 M, Ro 40-8757 was found to exert a high antiproliferative action with similar inhibitory potency (IC50) in drug-resistant and parental cell lines (range, 0.06 × 10-6 to 0.57 × 10-6 M). We conclude that: (1) thymidylate synthase is not involved in the mechanism of action of Ro 40-8757; (2) the mdrl gene product does not recognize this retinoic derivative; and (3) Ro 40-8757, alone or in combinations with other cytotoxic drugs, can be very useful in patients with progressive disease after conventional chemotherapy.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalCancer Letters
Volume85
Issue number1
DOIs
StatePublished - 30 Sep 1994

Keywords

  • Breast cancer
  • Colon cancer
  • Drug resistance
  • Retinoids
  • Ro 40-8757

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