Abstract
We have examined the antiproliferative effects of the arotinoid Ro 40-8757 in 3 drug-resistant human adenocarcinoma cell lines: the colonic cells HT29-5FU and CaCo2, and the mammary cells MCF-7mdrl. Whereas all-trans retinoic acid had no effect at the concentration of 10-6 M, Ro 40-8757 was found to exert a high antiproliferative action with similar inhibitory potency (IC50) in drug-resistant and parental cell lines (range, 0.06 × 10-6 to 0.57 × 10-6 M). We conclude that: (1) thymidylate synthase is not involved in the mechanism of action of Ro 40-8757; (2) the mdrl gene product does not recognize this retinoic derivative; and (3) Ro 40-8757, alone or in combinations with other cytotoxic drugs, can be very useful in patients with progressive disease after conventional chemotherapy.
Original language | English |
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Pages (from-to) | 83-86 |
Number of pages | 4 |
Journal | Cancer Letters |
Volume | 85 |
Issue number | 1 |
DOIs | |
State | Published - 30 Sep 1994 |
Keywords
- Breast cancer
- Colon cancer
- Drug resistance
- Retinoids
- Ro 40-8757