The arotinoid Ro 40-8757 has antiproliferative effects in drug-resistant human colon and breast cancer cell lines in vitro

Christophe Louvet; Sylvie Empereur; Dominique Fagot; Elisabeth Forgue-Lafitte; Eric Chastre; Amazia Zimber; Jan Mester; Christian Gespach

doi:10.1016/0304-3835(94)90242-9

The arotinoid Ro 40-8757 has antiproliferative effects in drug-resistant human colon and breast cancer cell lines in vitro

Christophe Louvet^*
, Sylvie Empereur
, Dominique Fagot
, Elisabeth Forgue-Lafitte
, Eric Chastre
, Amazia Zimber
, Jan Mester
, Christian Gespach

^*Corresponding author for this work

Department of Animal Sciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We have examined the antiproliferative effects of the arotinoid Ro 40-8757 in 3 drug-resistant human adenocarcinoma cell lines: the colonic cells HT29-5FU and CaCo2, and the mammary cells MCF-7mdrl. Whereas all-trans retinoic acid had no effect at the concentration of 10^-6 M, Ro 40-8757 was found to exert a high antiproliferative action with similar inhibitory potency (IC₅₀) in drug-resistant and parental cell lines (range, 0.06 × 10^-6 to 0.57 × 10^-6 M). We conclude that: (1) thymidylate synthase is not involved in the mechanism of action of Ro 40-8757; (2) the mdrl gene product does not recognize this retinoic derivative; and (3) Ro 40-8757, alone or in combinations with other cytotoxic drugs, can be very useful in patients with progressive disease after conventional chemotherapy.

Original language	English
Pages (from-to)	83-86
Number of pages	4
Journal	Cancer Letters
Volume	85
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(94)90242-9
State	Published - 30 Sep 1994

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
Colon cancer
Drug resistance
Retinoids
Ro 40-8757

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10.1016/0304-3835(94)90242-9

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title = "The arotinoid Ro 40-8757 has antiproliferative effects in drug-resistant human colon and breast cancer cell lines in vitro",

abstract = "We have examined the antiproliferative effects of the arotinoid Ro 40-8757 in 3 drug-resistant human adenocarcinoma cell lines: the colonic cells HT29-5FU and CaCo2, and the mammary cells MCF-7mdrl. Whereas all-trans retinoic acid had no effect at the concentration of 10-6 M, Ro 40-8757 was found to exert a high antiproliferative action with similar inhibitory potency (IC50) in drug-resistant and parental cell lines (range, 0.06 × 10-6 to 0.57 × 10-6 M). We conclude that: (1) thymidylate synthase is not involved in the mechanism of action of Ro 40-8757; (2) the mdrl gene product does not recognize this retinoic derivative; and (3) Ro 40-8757, alone or in combinations with other cytotoxic drugs, can be very useful in patients with progressive disease after conventional chemotherapy.",

keywords = "Breast cancer, Colon cancer, Drug resistance, Retinoids, Ro 40-8757",

author = "Christophe Louvet and Sylvie Empereur and Dominique Fagot and Elisabeth Forgue-Lafitte and Eric Chastre and Amazia Zimber and Jan Mester and Christian Gespach",

year = "1994",

month = sep,

day = "30",

doi = "10.1016/0304-3835(94)90242-9",

language = "אנגלית",

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T1 - The arotinoid Ro 40-8757 has antiproliferative effects in drug-resistant human colon and breast cancer cell lines in vitro

AU - Louvet, Christophe

AU - Empereur, Sylvie

AU - Fagot, Dominique

AU - Forgue-Lafitte, Elisabeth

AU - Chastre, Eric

AU - Zimber, Amazia

AU - Mester, Jan

AU - Gespach, Christian

PY - 1994/9/30

Y1 - 1994/9/30

N2 - We have examined the antiproliferative effects of the arotinoid Ro 40-8757 in 3 drug-resistant human adenocarcinoma cell lines: the colonic cells HT29-5FU and CaCo2, and the mammary cells MCF-7mdrl. Whereas all-trans retinoic acid had no effect at the concentration of 10-6 M, Ro 40-8757 was found to exert a high antiproliferative action with similar inhibitory potency (IC50) in drug-resistant and parental cell lines (range, 0.06 × 10-6 to 0.57 × 10-6 M). We conclude that: (1) thymidylate synthase is not involved in the mechanism of action of Ro 40-8757; (2) the mdrl gene product does not recognize this retinoic derivative; and (3) Ro 40-8757, alone or in combinations with other cytotoxic drugs, can be very useful in patients with progressive disease after conventional chemotherapy.

AB - We have examined the antiproliferative effects of the arotinoid Ro 40-8757 in 3 drug-resistant human adenocarcinoma cell lines: the colonic cells HT29-5FU and CaCo2, and the mammary cells MCF-7mdrl. Whereas all-trans retinoic acid had no effect at the concentration of 10-6 M, Ro 40-8757 was found to exert a high antiproliferative action with similar inhibitory potency (IC50) in drug-resistant and parental cell lines (range, 0.06 × 10-6 to 0.57 × 10-6 M). We conclude that: (1) thymidylate synthase is not involved in the mechanism of action of Ro 40-8757; (2) the mdrl gene product does not recognize this retinoic derivative; and (3) Ro 40-8757, alone or in combinations with other cytotoxic drugs, can be very useful in patients with progressive disease after conventional chemotherapy.

KW - Breast cancer

KW - Colon cancer

KW - Drug resistance

KW - Retinoids

KW - Ro 40-8757

UR - https://www.scopus.com/pages/publications/0027984886

U2 - 10.1016/0304-3835(94)90242-9

DO - 10.1016/0304-3835(94)90242-9

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C2 - 7923106

AN - SCOPUS:0027984886

SN - 0304-3835

VL - 85

SP - 83

EP - 86

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

The arotinoid Ro 40-8757 has antiproliferative effects in drug-resistant human colon and breast cancer cell lines in vitro

Abstract

UN SDGs

Keywords

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