The association of genetically determined serum glycine with cardiovascular risk in East Asians

Xuling Chang; Ling Wang; Shou Ping Guan; Brian K. Kennedy; Jianjun Liu; Chiea Chuen Khor; Adrian F. Low; Mark Yan Yee Chan; Jian Min Yuan; Woon Puay Koh; Yechiel Friedlander; Rajkumar Dorajoo; Chew Kiat Heng

doi:10.1016/j.numecd.2021.03.010

The association of genetically determined serum glycine with cardiovascular risk in East Asians

Xuling Chang, Ling Wang, Shou Ping Guan, Brian K. Kennedy, Jianjun Liu, Chiea Chuen Khor, Adrian F. Low, Mark Yan Yee Chan, Jian Min Yuan, Woon Puay Koh, Yechiel Friedlander, Rajkumar Dorajoo^*, Chew Kiat Heng^*

^*Corresponding author for this work

Braun School of Public Health and Community Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background and aims: Glycine is involved in a wide range of metabolic pathways and increased circulating glycine is associated with reduced risk of cardio-metabolic diseases in Europeans but the genetic association between circulating glycine and cardiovascular risk is largely unknown in East Asians. Methods and results: We conducted a genome-wide association study (GWAS) in Singaporean Chinese participants and investigated if genetically determined serum glycine were associated with incident coronary artery disease (CAD) (711 cases and 1,246 controls), cardiovascular death (1,886 cases and 21,707 controls) and angiographic CAD severity (as determined by the Modified Gensini score, N = 1,138). Conclusion: Our study, a first in East Asians, suggest a protective role of glycine against CAD.

Original language	English
Pages (from-to)	1840-1844
Number of pages	5
Journal	Nutrition, Metabolism and Cardiovascular Diseases
Volume	31
Issue number	6
DOIs	https://doi.org/10.1016/j.numecd.2021.03.010
State	Published - 7 Jun 2021

Bibliographical note

Publisher Copyright:
© 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University

Keywords

Cardiovascular risk
Circulating glycine concentration
Genetic association
Genome-wide association study

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.numecd.2021.03.010

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Chang, X., Wang, L., Guan, S. P., Kennedy, B. K., Liu, J., Khor, C. C., Low, A. F., Chan, M. Y. Y., Yuan, J. M., Koh, W. P., Friedlander, Y., Dorajoo, R., & Heng, C. K. (2021). The association of genetically determined serum glycine with cardiovascular risk in East Asians. Nutrition, Metabolism and Cardiovascular Diseases, 31(6), 1840-1844. https://doi.org/10.1016/j.numecd.2021.03.010

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abstract = "Background and aims: Glycine is involved in a wide range of metabolic pathways and increased circulating glycine is associated with reduced risk of cardio-metabolic diseases in Europeans but the genetic association between circulating glycine and cardiovascular risk is largely unknown in East Asians. Methods and results: We conducted a genome-wide association study (GWAS) in Singaporean Chinese participants and investigated if genetically determined serum glycine were associated with incident coronary artery disease (CAD) (711 cases and 1,246 controls), cardiovascular death (1,886 cases and 21,707 controls) and angiographic CAD severity (as determined by the Modified Gensini score, N = 1,138). Conclusion: Our study, a first in East Asians, suggest a protective role of glycine against CAD.",

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author = "Xuling Chang and Ling Wang and Guan, {Shou Ping} and Kennedy, {Brian K.} and Jianjun Liu and Khor, {Chiea Chuen} and Low, {Adrian F.} and Chan, {Mark Yan Yee} and Yuan, {Jian Min} and Koh, {Woon Puay} and Yechiel Friedlander and Rajkumar Dorajoo and Heng, {Chew Kiat}",

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AU - Wang, Ling

AU - Guan, Shou Ping

AU - Kennedy, Brian K.

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AU - Khor, Chiea Chuen

AU - Low, Adrian F.

AU - Chan, Mark Yan Yee

AU - Yuan, Jian Min

AU - Koh, Woon Puay

AU - Friedlander, Yechiel

AU - Dorajoo, Rajkumar

AU - Heng, Chew Kiat

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PY - 2021/6/7

Y1 - 2021/6/7

N2 - Background and aims: Glycine is involved in a wide range of metabolic pathways and increased circulating glycine is associated with reduced risk of cardio-metabolic diseases in Europeans but the genetic association between circulating glycine and cardiovascular risk is largely unknown in East Asians. Methods and results: We conducted a genome-wide association study (GWAS) in Singaporean Chinese participants and investigated if genetically determined serum glycine were associated with incident coronary artery disease (CAD) (711 cases and 1,246 controls), cardiovascular death (1,886 cases and 21,707 controls) and angiographic CAD severity (as determined by the Modified Gensini score, N = 1,138). Conclusion: Our study, a first in East Asians, suggest a protective role of glycine against CAD.

AB - Background and aims: Glycine is involved in a wide range of metabolic pathways and increased circulating glycine is associated with reduced risk of cardio-metabolic diseases in Europeans but the genetic association between circulating glycine and cardiovascular risk is largely unknown in East Asians. Methods and results: We conducted a genome-wide association study (GWAS) in Singaporean Chinese participants and investigated if genetically determined serum glycine were associated with incident coronary artery disease (CAD) (711 cases and 1,246 controls), cardiovascular death (1,886 cases and 21,707 controls) and angiographic CAD severity (as determined by the Modified Gensini score, N = 1,138). Conclusion: Our study, a first in East Asians, suggest a protective role of glycine against CAD.

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KW - Circulating glycine concentration

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The association of genetically determined serum glycine with cardiovascular risk in East Asians

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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