The association of H‐2 antigens and EAC receptors on the surface of peritoneal cells

M. Schlesinger*, M. Chaouat

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The exposure of murine peritoneal cells to anti‐H‐2 sera results in a diminished expressoion of H‐2 antigen on the cell surface. Concomitant with this „H‐2 modulation” the capacity of macrphages to bind sheep red blood cells coated with antibody and complement (EAC) was markedly diminished. In contrast, there was no change in the capacity of modulated macrophages to bind sheep red blood cells coated with antibody alone (EA). Antibodies to K end H‐2 specificities were more effective in reducing the binding of EAC than antibodies to D end H‐2 specificities. Exposure of peritoneal cells to θ or Ly antisera had no effect on the formation of EAC rosettes. Exposure of pertioneal cells to anti‐H‐2 sera, under conditions which would not allow moudulation of H‐2 antigens, also prevented the reduction of EAC binding. Thus, the EAC receptors and H‐2 antigenic specificities seem to be closely related on the surface of peritoneal cells, but constitute distinct cell surface structures. Perliminary evidence indicates that vinblastine, a microtubule depolymerizing agent, may disrupt the close association of EAC receptors and H‐2 antigens. It is suggested that the association of EAC receptors and K end H‐2 determinants on the membrane of macrphages may have implications for the regulations of the immune response by H‐2‐linked Ir genes.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalEuropean Journal of Immunology
Volume5
Issue number1
DOIs
StatePublished - Jan 1975

Fingerprint

Dive into the research topics of 'The association of H‐2 antigens and EAC receptors on the surface of peritoneal cells'. Together they form a unique fingerprint.

Cite this