The association of the SNAP-25 gene polymorphism with verbal memory and attention in patients with major psychosis and healthy people

V. E. Goumbet; M. V. Alfimova; I. K. Gritsenko; T. V. Lezheiko; O. M. Lavrushina; L. I. Abramova; V. G. Kaleda; A. N. Barkhatova; A. V. Sokolov; R. P. Ebstein

The association of the SNAP-25 gene polymorphism with verbal memory and attention in patients with major psychosis and healthy people

V. E. Goumbet
, M. V. Alfimova
, I. K. Gritsenko
, T. V. Lezheiko
, O. M. Lavrushina
, L. I. Abramova
, V. G. Kaleda
, A. N. Barkhatova
, A. V. Sokolov
, R. P. Ebstein

Department of Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

The synaptosomal-associated protein (SNAP-25) plays an integral role in synaptic transmission and in memory consolidation in the hippocampus. Recently an association between SNAP-25 gene polymorphism and cognitive ability has been reported in two independent studies of healthy people and patients with schizophrenia. Authors carried out an association study of Mnll SNAP-25 polymorphism and performance on neurocognitive tests measuring verbal memory, attention/executive functions in 66 patients with major psychosis, 75 their relatives and 136 controls. MANCOVA revealed a significant effect of group (p=0,00001) and genotype (p=0,012) as well as an interaction effect between group and genotype (p=0,02) on the performance on neurocognitive tests. Carriers of the TT genotype performed worse on the most tasks compared to other genotypes. The similar character of the Mnll SNAP-25 polymorphism effect on the variability of neurocognitive traits in all groups suggests the relationship between this gene and general cognitive ability.

Original language	English
Pages (from-to)	59-63
Number of pages	5
Journal	Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova
Volume	109
Issue number	1
State	Published - 2009

Keywords

Attention
General cognitive ability
Memory
Schizophrenia
Snap-25 gene

Cite this

Goumbet, V. E., Alfimova, M. V., Gritsenko, I. K., Lezheiko, T. V., Lavrushina, O. M., Abramova, L. I., Kaleda, V. G., Barkhatova, A. N., Sokolov, A. V., & Ebstein, R. P. (2009). The association of the SNAP-25 gene polymorphism with verbal memory and attention in patients with major psychosis and healthy people. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova, 109(1), 59-63.

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abstract = "The synaptosomal-associated protein (SNAP-25) plays an integral role in synaptic transmission and in memory consolidation in the hippocampus. Recently an association between SNAP-25 gene polymorphism and cognitive ability has been reported in two independent studies of healthy people and patients with schizophrenia. Authors carried out an association study of Mnll SNAP-25 polymorphism and performance on neurocognitive tests measuring verbal memory, attention/executive functions in 66 patients with major psychosis, 75 their relatives and 136 controls. MANCOVA revealed a significant effect of group (p=0,00001) and genotype (p=0,012) as well as an interaction effect between group and genotype (p=0,02) on the performance on neurocognitive tests. Carriers of the TT genotype performed worse on the most tasks compared to other genotypes. The similar character of the Mnll SNAP-25 polymorphism effect on the variability of neurocognitive traits in all groups suggests the relationship between this gene and general cognitive ability.",

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AU - Lavrushina, O. M.

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AU - Ebstein, R. P.

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AB - The synaptosomal-associated protein (SNAP-25) plays an integral role in synaptic transmission and in memory consolidation in the hippocampus. Recently an association between SNAP-25 gene polymorphism and cognitive ability has been reported in two independent studies of healthy people and patients with schizophrenia. Authors carried out an association study of Mnll SNAP-25 polymorphism and performance on neurocognitive tests measuring verbal memory, attention/executive functions in 66 patients with major psychosis, 75 their relatives and 136 controls. MANCOVA revealed a significant effect of group (p=0,00001) and genotype (p=0,012) as well as an interaction effect between group and genotype (p=0,02) on the performance on neurocognitive tests. Carriers of the TT genotype performed worse on the most tasks compared to other genotypes. The similar character of the Mnll SNAP-25 polymorphism effect on the variability of neurocognitive traits in all groups suggests the relationship between this gene and general cognitive ability.

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The association of the SNAP-25 gene polymorphism with verbal memory and attention in patients with major psychosis and healthy people

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Keywords

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