The breaking beads approach for photocleavage from solid support

Yasmeen Bakhatan, Israel Alshanski, Dana Grunhaus, Mattan Hurevich*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Photocleavage from polystyrene beads is a pivotal reaction for solid phase synthesis that relies on photolabile linkers. Photocleavage from intact porous polystyrene beads is not optimal because light cannot penetrate into the beads and the surface area exposed to irradiation is limited. Thus, hazardous, technically challenging and expensive setups are used for photocleavage from intact beads. We developed a new concept in which grinding the beads during or prior to irradiation is employed as an essential part of the photocleavage process. By grinding the beads we are exposing more surface area to the light source, hence, photocleavage can be performed even using a simple benchtop LED setup. This approach proved very efficient for photocleavage of various model compounds including fully protected oligosaccharides.

Original languageAmerican English
Pages (from-to)4183-4188
Number of pages6
JournalOrganic and Biomolecular Chemistry
Issue number22
StatePublished - 14 Jun 2020

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2020.


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