The burst of mitochondrial diseases: Neurons and calcium

A. Fendyur, I. Kaiserman, L. Kasinetz, R. Rahamimoff

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


In summary, it seems that in many neurologic disorders - of both genetic and toxic origin - mitochondrial disruption leads to an altered calcium metabolism and thus to cell death. This raises the possibility that various protective agents, such as antioxidants, that improve mitochondrial function efficiency, may be of benefit in high risk individuals.
Original languageEnglish
Pages (from-to)356-359
Number of pages4
JournalIsrael Medical Association Journal
Issue number6
StatePublished - 2004

Bibliographical note

Cited By :1

Export Date: 11 September 2022


Correspondence Address: Rahamimoff, R.; Dept. of Physiology, , Jerusalem 91120, Israel; email:

Chemicals/CAS: 1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine, 28289-54-5; adenine, 22177-51-1, 2922-28-3, 73-24-5; calcium ion, 14127-61-8; cyclosporin A, 59865-13-3, 63798-73-2; cytosine, 71-30-7; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; guanine, 69257-39-2, 73-40-5; huntingtin, 191683-04-2; manganese, 16397-91-4, 7439-96-5; reduced nicotinamide adenine dinucleotide dehydrogenase, 9027-14-9, 9032-21-7, 9079-67-8; rotenone, 83-79-4; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; calcium, 7440-70-2; Calcium, 7440-70-2

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  • Calcium
  • Genetic disease
  • Mitochondria
  • Neurotoxicity
  • Oxidative stress
  • 1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine
  • adenine
  • antioxidant
  • calcium ion
  • cyclosporin A
  • cytosine
  • glutamic acid
  • guanine
  • huntingtin
  • manganese
  • mitochondrial DNA
  • phosphatidylinositol 3,4,5 trisphosphate
  • reactive oxygen metabolite
  • reduced nicotinamide adenine dinucleotide dehydrogenase
  • rotenone
  • superoxide dismutase
  • calcium
  • Alzheimer disease
  • amyotrophic lateral sclerosis
  • apoptosis
  • autophagy
  • calcium homeostasis
  • calcium metabolism
  • calcium signaling
  • calcium transport
  • cell death
  • disorders of mitochondrial functions
  • gene mutation
  • high risk patient
  • human
  • Huntington chorea
  • Leber hereditary optic neuropathy
  • neurofibrillary tangle
  • neurologic disease
  • oxidative stress
  • Parkinson disease
  • point mutation
  • review
  • senile plaque
  • transport kinetics
  • trinucleotide repeat
  • metabolism
  • nerve cell
  • pathophysiology
  • physiology
  • Alzheimer Disease
  • Amyotrophic Lateral Sclerosis
  • Humans
  • Huntington Disease
  • Mitochondrial Diseases
  • Neurons
  • Optic Atrophy, Hereditary, Leber
  • Parkinson Disease


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