The 'Ca-voltage' hypothesis for neurotransmifter release

I. Parnas; H. Parnas

doi:10.1016/0301-4622(88)87027-3

The 'Ca-voltage' hypothesis for neurotransmifter release

I. Parnas^*, H. Parnas

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The 'Ca-voltage' hypothesis for neurotransmitter release was reinvestigated by studying the kinetics of neurotransmitter release. These were independent of in intracellular or extracellular Ca²⁺ concentration. It is concluded that initiation and termination of release do not result from rapid entry and removal of Ca²⁺ although Ca²⁺ is essential for release. Quantal release of transmitter requires depolarization-dependent transformation of a membrane molecule from an inactive form T to a Ca²⁺-binding form S. The depolarization-dependent T → S transformation initiates release in the presence of Ca²⁺. The S → T transformation upon repolarization stops release even though the Ca²⁺ concentration at release sites is still high.

Original language	English
Pages (from-to)	85-93
Number of pages	9
Journal	Biophysical Chemistry
Volume	29
Issue number	1-2
DOIs	https://doi.org/10.1016/0301-4622(88)87027-3
State	Published - Feb 1988

Keywords

Ca channel
Membrane potential
Neurotransmitter release

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10.1016/0301-4622(88)87027-3

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The 'Ca-voltage' hypothesis for neurotransmifter release

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