The CCR5Δ32 allele is associated with reduced liver inflammation in hepatitis C virus infection

  • O. Wald
  • , O. Pappo
  • , Z. B. Ari
  • , E. Azzaria
  • , I. D. Wiess
  • , I. Gafnovitch
  • , H. Wald
  • , U. Spengler
  • , E. Galun
  • , Amnon Peled*
  • *Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

CCR5Δ32 is a deletion mutation in the chemokine receptor CCR5. Liver inflammatory activity was found to be significantly reduced (P = 0.005) in Jewish Israeli patients infected with the hepatitis C virus (HCV) carrying the CCR5Δ32 allele. The CCR5Δ32 allele does not alter susceptibility to HCV infection; however, it may play a role in the progression and outcome of the disease.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalEuropean Journal of Immunogenetics
Volume31
Issue number6
DOIs
StatePublished - Dec 2004
Externally publishedYes

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