The "cellular state": The way to regain specificity and diversity in hormone action

D. Lichtstein*, H. Atlan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

In contrast with the high specificity achieved in the effects of hormones and growth factors by their interaction with a large number of membrane receptors, a loss of information seems to take place due to the small number of second messenger systems. To retain specificity one has to consider the cellular state as defined in a state machine by a pattern of activity. Different molecular mechanisms are considered as possible candidates to establish such states following the initial ligand-receptor interaction and the activation of one or several second messengers.

Original languageEnglish
Pages (from-to)287-294
Number of pages8
JournalJournal of Theoretical Biology
Volume145
Issue number3
DOIs
StatePublished - 9 Aug 1990

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