TY - JOUR
T1 - The "cellular state"
T2 - The way to regain specificity and diversity in hormone action
AU - Lichtstein, D.
AU - Atlan, H.
PY - 1990/8/9
Y1 - 1990/8/9
N2 - In contrast with the high specificity achieved in the effects of hormones and growth factors by their interaction with a large number of membrane receptors, a loss of information seems to take place due to the small number of second messenger systems. To retain specificity one has to consider the cellular state as defined in a state machine by a pattern of activity. Different molecular mechanisms are considered as possible candidates to establish such states following the initial ligand-receptor interaction and the activation of one or several second messengers.
AB - In contrast with the high specificity achieved in the effects of hormones and growth factors by their interaction with a large number of membrane receptors, a loss of information seems to take place due to the small number of second messenger systems. To retain specificity one has to consider the cellular state as defined in a state machine by a pattern of activity. Different molecular mechanisms are considered as possible candidates to establish such states following the initial ligand-receptor interaction and the activation of one or several second messengers.
UR - http://www.scopus.com/inward/record.url?scp=0024986474&partnerID=8YFLogxK
U2 - 10.1016/S0022-5193(05)80110-9
DO - 10.1016/S0022-5193(05)80110-9
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C2 - 2172656
AN - SCOPUS:0024986474
SN - 0022-5193
VL - 145
SP - 287
EP - 294
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
IS - 3
ER -