The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation

Elyad Lezmi, Uri Weissbein, Tamar Golan-Lev, Malka Nissim-Rafinia, Eran Meshorer*, Nissim Benvenisty*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

In this article Lezmi et al. identified the chromatin regulator, ZMYM2, as a major epigenetic factor involved in human ESCs growth, and showed that its loss causes adverse transcriptional and epigenetic changes. ZMYM2-null ESCs overexpress naive pluripotency genes while losing their capacity to properly differentiate in vitro and form teratomas in vivo.

Original languageAmerican English
Pages (from-to)1275-1286
Number of pages12
JournalStem Cell Reports
Volume15
Issue number6
DOIs
StatePublished - 8 Dec 2020

Bibliographical note

Publisher Copyright:
© 2020 The Authors

Keywords

  • chromatin
  • differentiation
  • human pluripotent stem cells
  • naive cells
  • primed cells
  • teratoma

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