The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation

Elyad Lezmi; Uri Weissbein; Tamar Golan-Lev; Malka Nissim-Rafinia; Eran Meshorer; Nissim Benvenisty

doi:10.1016/j.stemcr.2020.05.014

The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation

Elyad Lezmi, Uri Weissbein, Tamar Golan-Lev, Malka Nissim-Rafinia, Eran Meshorer^*, Nissim Benvenisty^*

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

In this article Lezmi et al. identified the chromatin regulator, ZMYM2, as a major epigenetic factor involved in human ESCs growth, and showed that its loss causes adverse transcriptional and epigenetic changes. ZMYM2-null ESCs overexpress naive pluripotency genes while losing their capacity to properly differentiate in vitro and form teratomas in vivo.

Original language	American English
Pages (from-to)	1275-1286
Number of pages	12
Journal	Stem Cell Reports
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/j.stemcr.2020.05.014
State	Published - 8 Dec 2020

Bibliographical note

Funding Information:
The authors thank Yishai Avior for critically reading the manuscript. N.B. is the Herbert Cohn Chair in Cancer Research. This work was partially supported by the U.S-Israel Binational Science Foundation (grant 2015089 ), by the Israel Science Foundation (grant 494/17 ), by the Rosetrees Trust , and by the Azrieli Foundation .

Publisher Copyright:
© 2020 The Authors

Keywords

chromatin
differentiation
human pluripotent stem cells
naive cells
primed cells
teratoma

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10.1016/j.stemcr.2020.05.014

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title = "The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation",

abstract = "In this article Lezmi et al. identified the chromatin regulator, ZMYM2, as a major epigenetic factor involved in human ESCs growth, and showed that its loss causes adverse transcriptional and epigenetic changes. ZMYM2-null ESCs overexpress naive pluripotency genes while losing their capacity to properly differentiate in vitro and form teratomas in vivo.",

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note = "Funding Information: The authors thank Yishai Avior for critically reading the manuscript. N.B. is the Herbert Cohn Chair in Cancer Research. This work was partially supported by the U.S-Israel Binational Science Foundation (grant 2015089 ), by the Israel Science Foundation (grant 494/17 ), by the Rosetrees Trust , and by the Azrieli Foundation . Publisher Copyright: {\textcopyright} 2020 The Authors",

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doi = "10.1016/j.stemcr.2020.05.014",

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AU - Golan-Lev, Tamar

AU - Nissim-Rafinia, Malka

AU - Meshorer, Eran

AU - Benvenisty, Nissim

N1 - Funding Information: The authors thank Yishai Avior for critically reading the manuscript. N.B. is the Herbert Cohn Chair in Cancer Research. This work was partially supported by the U.S-Israel Binational Science Foundation (grant 2015089 ), by the Israel Science Foundation (grant 494/17 ), by the Rosetrees Trust , and by the Azrieli Foundation . Publisher Copyright: © 2020 The Authors

PY - 2020/12/8

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N2 - In this article Lezmi et al. identified the chromatin regulator, ZMYM2, as a major epigenetic factor involved in human ESCs growth, and showed that its loss causes adverse transcriptional and epigenetic changes. ZMYM2-null ESCs overexpress naive pluripotency genes while losing their capacity to properly differentiate in vitro and form teratomas in vivo.

AB - In this article Lezmi et al. identified the chromatin regulator, ZMYM2, as a major epigenetic factor involved in human ESCs growth, and showed that its loss causes adverse transcriptional and epigenetic changes. ZMYM2-null ESCs overexpress naive pluripotency genes while losing their capacity to properly differentiate in vitro and form teratomas in vivo.

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KW - differentiation

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KW - primed cells

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The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation

Abstract

Bibliographical note

Keywords

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