Abstract
In this article Lezmi et al. identified the chromatin regulator, ZMYM2, as a major epigenetic factor involved in human ESCs growth, and showed that its loss causes adverse transcriptional and epigenetic changes. ZMYM2-null ESCs overexpress naive pluripotency genes while losing their capacity to properly differentiate in vitro and form teratomas in vivo.
Original language | American English |
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Pages (from-to) | 1275-1286 |
Number of pages | 12 |
Journal | Stem Cell Reports |
Volume | 15 |
Issue number | 6 |
DOIs | |
State | Published - 8 Dec 2020 |
Bibliographical note
Funding Information:The authors thank Yishai Avior for critically reading the manuscript. N.B. is the Herbert Cohn Chair in Cancer Research. This work was partially supported by the U.S-Israel Binational Science Foundation (grant 2015089 ), by the Israel Science Foundation (grant 494/17 ), by the Rosetrees Trust , and by the Azrieli Foundation .
Publisher Copyright:
© 2020 The Authors
Keywords
- chromatin
- differentiation
- human pluripotent stem cells
- naive cells
- primed cells
- teratoma