In this article Lezmi et al. identified the chromatin regulator, ZMYM2, as a major epigenetic factor involved in human ESCs growth, and showed that its loss causes adverse transcriptional and epigenetic changes. ZMYM2-null ESCs overexpress naive pluripotency genes while losing their capacity to properly differentiate in vitro and form teratomas in vivo.
Bibliographical noteFunding Information:
The authors thank Yishai Avior for critically reading the manuscript. N.B. is the Herbert Cohn Chair in Cancer Research. This work was partially supported by the U.S-Israel Binational Science Foundation (grant 2015089 ), by the Israel Science Foundation (grant 494/17 ), by the Rosetrees Trust , and by the Azrieli Foundation .
© 2020 The Authors
- human pluripotent stem cells
- naive cells
- primed cells