The comparative roles of dopaminergic and serotonergic mechanisms in mediating quipazine induced increases in locomotor acitivity

J. J. Feigenbaum*, J. Yanai, H. L. Klawans

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The effect of dopaminergic and serotonergic agonists and antagonists on quipazine induced locomotor activity was investigated in rats. Though quipazine is generally considered to be a relatively pure serotonergic agonist, its effects on locomotor activity were inhibited by small doses of a centrally acting DA receptor blocking agent (haloperidol), while three different serotonergic (5-HT) antagonists were without effect on this behavior. Moreover, quipazine induced locomotor activity was markedly inhibited by the 5-HT substrate 5-hydroxytryptophan. The data suggest that quipazine induced locomotor activity primarily involves dopaminergic mechanisms, with 5-HT playing either no role in stimulating this behavior, or a subsidiary one, requiring intact central dopaminergic receptors for its expression.

Original languageEnglish
Pages (from-to)27-37
Number of pages11
JournalJournal of Neural Transmission
Volume57
Issue number1-2
DOIs
StatePublished - Mar 1983

Fingerprint

Dive into the research topics of 'The comparative roles of dopaminergic and serotonergic mechanisms in mediating quipazine induced increases in locomotor acitivity'. Together they form a unique fingerprint.

Cite this