The complete peptide dictionary - A meta-proteomics resource

Manor Askenazi, Jarrod A. Marto, Michal Linial*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Recent developments in MS-based proteomics have increased the emphasis on peptides as a primary observable. While peptides are identified by tandem mass spectra, the link between peptide and protein remains implicit given the bottom-up nature of the experiment in which proteins are enzymatically digested prior to sequencing. It is therefore useful to provide a fast lookup from peptide to protein in order to systematically establish the broadest possible protein basis for the observed peptides. Here, we describe Pep2Pro, a fast web-service providing protein lookup by peptides covering the entire protein space comprising -10 million UniRef100 sequences. We demonstrate the usefulness of the service by reanalyzing peptides from two recent meta-proteomic data sets and identifying taxon-specific peptides, thereby implicating individual species as being present in these complex samples. The Pep2Pro web service can be accessed at

Original languageAmerican English
Pages (from-to)4306-4310
Number of pages5
Issue number23
StatePublished - Dec 2010


  • Bioinformatics
  • MS proteomics
  • Peptides
  • RESTful interface
  • Web service


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