Common fragile sites (CFSs) are chromosomal regions characterized as hotspots for breakage and chromosomal rearrangements following DNA replication stress. They are preferentially unstable in pre-cancerous lesions and during cancer development. Recently CFSs were found to be tissue- and even oncogene-induced specific, thus indicating an unforeseen complexity. Here we review recent developments in CFS research that shed new light on the molecular basis of their instability and their importance in cancer development.
Bibliographical noteFunding Information:
This work was partially supported by grants from the Israel Science Foundation (Grant No. 176/11), The Chief Scientist Office of the Israel Ministry of Health (Grant No. 3-00000-6014), the Israeli Cancer Association (grant No. 20141044), and by the Israeli centers of research excellence (I-CORE), Gene Regulation in Complex Human Disease, Center Number 41/11. We thank Tamar Lev-Golan for assistance in generating the figure and all members of the Kerem lab for thoughtful discussions and advice.
© 2016 Elsevier Ltd.