TY - JOUR
T1 - The complex nature of fragile site plasticity and its importance in cancer
AU - Sarni, Dan
AU - Kerem, Batsheva
N1 - Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Common fragile sites (CFSs) are chromosomal regions characterized as hotspots for breakage and chromosomal rearrangements following DNA replication stress. They are preferentially unstable in pre-cancerous lesions and during cancer development. Recently CFSs were found to be tissue- and even oncogene-induced specific, thus indicating an unforeseen complexity. Here we review recent developments in CFS research that shed new light on the molecular basis of their instability and their importance in cancer development.
AB - Common fragile sites (CFSs) are chromosomal regions characterized as hotspots for breakage and chromosomal rearrangements following DNA replication stress. They are preferentially unstable in pre-cancerous lesions and during cancer development. Recently CFSs were found to be tissue- and even oncogene-induced specific, thus indicating an unforeseen complexity. Here we review recent developments in CFS research that shed new light on the molecular basis of their instability and their importance in cancer development.
UR - http://www.scopus.com/inward/record.url?scp=84962385724&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2016.03.017
DO - 10.1016/j.ceb.2016.03.017
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 27062332
AN - SCOPUS:84962385724
SN - 0955-0674
VL - 40
SP - 131
EP - 136
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -
