The compositional development of the microbiome in early life

Avital Cher, Moran Yassour

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

As the infant transitions from the isolated womb of its mother to the outside word, there are suddenly countless new sources for the acquisition of microbes. By studying which microbes succeed in making their home in the infant gut and which ones are lost, we can improve our understanding of why and how this selection process takes place. Research that includes longitudinal and dense sampling has allowed for the observation of the succession of bacterial populations throughout early development, and by utilizing sequencing tools that enable analysis at the strain level, we have found distinct patterns of transmission from the mother to the infant. Although many questions remain to be answered, current findings suggest that a balance of positive and negative selection drives the formation of ecological niches, where groups of bacteria are selected to perform tasks, creating a cost-effective community in the infant gut that benefits both the microbiota and their host.

Original languageAmerican English
Title of host publicationThe Human Microbiome in Early Life
Subtitle of host publicationImplications to Health and Disease
PublisherElsevier
Pages177-195
Number of pages19
ISBN (Electronic)9780128180976
ISBN (Print)9780128180983
DOIs
StatePublished - 1 Jan 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc. All rights reserved.

Keywords

  • Infant gut
  • ecological niches
  • microbial composition
  • mother-to-child bacterial inheritance
  • species diversity
  • strain transmission

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