The Continental Divide: Anti-TNF Use in Pediatric IBD Is Different in North America Compared to Other Parts of the World

Peter C. Church*, Jeffrey Hyams, Frank Ruemmele, Lissy De Ridder, Dan Turner, Anne M. Griffiths

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Background and Aims. Use of anti-TNF therapies varies internationally. As an initiative of the international Pediatric IBD Network (PIBDNet), we compared global pediatric IBD anti-TNF practice patterns. Methods. Physicians were surveyed about anti-TNF use in Crohn's disease (CD) and ulcerative colitis (UC). Chi-squared, independent samples Mann-Whitney U, or related samples Wilcoxon signed rank tests were used to compare groups. Results. 344 physicians treating pediatric IBD responded from 43 countries (54% North America, 29% Europe, 6% Oceania, 6% Asia, 3% Africa, and 2% South America). Respondents treated a median 40 IBD patients. CD was more commonly treated with anti-TNF than UC (40% vs. 10%, p<0.001). North Americans more often used anti-TNF (median 50% vs. 30%, p<0.001) and before immunomodulator (80% vs. 35% CD, p<0.001; 76% vs. 43% steroid-dependent UC, p<0.001). Anti-TNF monotherapy was more common in North America. Anti-TNF in combination with methotrexate, instead of thiopurine, characterized North American practices. North Americans more often continued immunomodulator indefinitely and less often adhered to standard infliximab induction dosing. Access limitations were more common outside North America and Europe for both CD (67% vs. 31%, p<0.001) and UC (62% vs. 33%, p<0.001). Conclusions. Anti-TNF use in North America varies significantly from elsewhere.

Original languageAmerican English
Article number3190548
JournalCanadian Journal of Gastroenterology and Hepatology
StatePublished - 2018

Bibliographical note

Funding Information:
Peter C. Church has received consultancy fees from Abbvie, Ferring, and Janssen and research support from Abbvie. Jeffrey Hyams has received consultancy fees from Janssen, Abb-vie, Celgene, Takeda, Astra Zeneca, Receptos, Soligenix, Lilly, and Boehringer Ingelheim. Frank Ruemmele has received lecture fees from Shering-Plough, Nestlé, MeadJohnson, Ferring, MSD, Johnson & Johnson, Centocor, and Abbvie and consultancy fees from Johnson & Johnson, AbbVie, MSD France, Nestlé Nutrition Institute, and Nestlé Health Science. Lissy de Ridder has received lecture fees from MSD, consultancy fees from Shire, and research support from Shire, Merck, Janssen, and Abbvie. Dan Turner has received lecture fees from Abbvie and Janssen and consultancy fees from Abbvie, Janssen and Takeda. Anne M. Griffiths has received consultancy fees from Abbvie, Janssen, and Receptos.

Publisher Copyright:
© 2018 Peter C. Church et al.


Dive into the research topics of 'The Continental Divide: Anti-TNF Use in Pediatric IBD Is Different in North America Compared to Other Parts of the World'. Together they form a unique fingerprint.

Cite this